Poly(A) polymerase (PAP) diversity in gene expression - Star-PAP vs canonical PAP
نویسندگان
چکیده
منابع مشابه
Pap smear.
A Pap smear, also known as Papanicoloau smear, is a microscopic examination of cells scraped from the cervix and is used to detect cancerous or pre-cancerous conditions of the cervix or other medical conditions. It was named after Dr. George N. Papanicoloau, who first described it in 1928 and since its introduction, the Pap smear has helped reduce cervical cancer incidence and mortality rates b...
متن کاملCKI isoforms α and ε regulate Star–PAP target messages by controlling Star–PAP poly(A) polymerase activity and phosphoinositide stimulation
Star-PAP is a non-canonical, nuclear poly(A) polymerase (PAP) that is regulated by the lipid signaling molecule phosphatidylinositol 4,5 bisphosphate (PI4,5P(2)), and is required for the expression of a select set of mRNAs. It was previously reported that a PI4,5P(2) sensitive CKI isoform, CKIα associates with and phosphorylates Star-PAP in its catalytic domain. Here, we show that the oxidative...
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Pap stain was first developed by Dr GN Papanicoloau in 1947 and since then it has been used successfully to screen cervical cancer. In fact, it has reduced the incidence of cervical cancer by 70% especially in developed countries having well planned screening programs. However, the stain has undergone various modifications from regressive conventional method to progressive rapid Pap staining wh...
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I have read the recent publication by Ujević et al. with great interest (1). The authors concluded that “Pap smear was not specifi c enough to demonstrate chlamydial infection (1)”. Indeed, the high prevalence of chlamydial infection among working women has been confi rmed in several settings around the world. Pap smear is a recommended routine test for these working women. However, there have ...
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Neutrophil (PMNL) function is influenced by factors released by other immune cells during the course of the immune response. We investigated the effect of neutrophil cell density and the effect of supernatant of the phagocytosis assay on the phagocytosis activity of PMNLs. The measurements were carried out with naive (control) PMNLs of healthy donors and with PMNLs obtained from patients with s...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2014
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2014.05.029